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Title of the article
Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome
List of authors
Kyle E. Simpson, Ravichandra Venkateshappa, Zhao Kai Pang, Shoaib Faizi, Glen F. Tibbits, and Tom W. Claydon
The journal in which the article is published
Frontiers in Physiology
https://doi.org/10.3389/fphys.2020.624129
A brief summary
Long QT Syndrome (LQTS) is a cardiac electrical disorder, typified by irregular heart rates and sudden death. One particular form, Long QT Syndrome Type 2 (LQTS2), is caused by dysfunction of a cardiac potassium channel called the human ether-a-go-go related gene, or hERG. hERG function is typically studied reductionist model cells, although increasingly human stem cell-derived cardiac cells can be used. However no whole animal context has been available for research until recently, when zebrafish made their entrance. With similar cardiac electrical properties to humans, and a well understood genome, they are proving a potent model for studying genetic and drug-induced LQTS2.
This post was originally posted on the SFU BPK Instagram account on March 19th, 2021.