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Title of the article
Cannabidiol protects against high glucose‐induced oxidative stress and cytotoxicity in cardiac voltage‐gated sodium channels
List of authors
Mohamed A. Fouda, Mohammad‐Reza Ghovanloo and Peter C. Ruben
The journal in which the article is published
British Journal of Pharmacology doi: 10.1111/bph.15020. Epub 2020 Mar 10.PMID: 32077098
Paper summary
Diabetes is a metabolic disorder strongly associated with cardiovascular disease, especially cardiac arrhythmias. One of the proteins affected by hyperglycemia is the voltage-gated sodium channel, also called Nav1.5, which—along with other ion channels—is responsible for the electrical signal leading to the heartbeat. We found that that high glucose caused Nav1.5 to function abnormally, and that cannabidiol, the main non-psychotropic component of Cannabis, rescued normal Nav1.5 function both by directly affecting Nav1.5 and through its antioxidant properties. Notably, cannabidiol is approved for treating a seizure disorder caused by the same abnormal sodium channel function in the brain.
This post was originally posted on the SFU BPK Instagram account on February 5th, 2021.