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Title of the article
Drug screening platform using human induced pluripotent stem cell-derived atrial cardiomyocytes and optical mapping
List of authors
Marvin G. Gunawan*, Sarabjit S. Sangha*, Sanam Shafaattalab*, Eric Lin, Danielle A. Heims-Waldron, Vassilios J. Bezzerides, Zachary Laksman, Glen F. Tibbits
The journal in which the article is published
Stem Cells Translational Medicine
doi: 10.1002/sctm.19-0440. Online ahead of print.
PMID: 32927497
A brief summary
Our study aimed to overcome the difficulty of translating findings from the lab to the patients of atrial fibrillation, the most common heart rhythm disorder affecting the upper chambers of the heart. In this work, we developed a cell-based drug screening platform by using human induced pluripotent stem cell-derived atrial heart cells and optical mapping, a unique image analysis technique. The generated atrial heart cells have responses to drugs that are specific to the atria, and molecular profiles and key functional signatures reflecting human biology. This platform can be readily applied as a relevant tool in drug development efforts of potential atrial fibrillation therapies.
This post was originally posted on the SFU BPK Instagram account on February 11th, 2021.